A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells.
نویسندگان
چکیده
Nuclear estrogen receptor from MCF-7 cells undergoes a time-dependent, hormone-inducible transformation to a form that is less extractable from nuclei and less exchangeable with ligand. This receptor-modifying, intranuclear event is independent of receptor loss (processing) and appears associated with hormone responsiveness (progesterone-receptor induction) in these cells. The magnitude of receptor loss, however, is variable and apparently not a prerequisite for hormone action to induce progesterone receptor.
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عنوان ژورنال:
- Science
دوره 225 4667 شماره
صفحات -
تاریخ انتشار 1984